(2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid

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Chemical Name:(2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid
CAS No.:1609261-17-7
Molecular Formula:C₂₂H₂₅NO₇
Molecular Weight:415.443
Hs Code.:

Synonyms:(2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid

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Chemical Property of (2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid

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Technology Process of (2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid

There total 5 articles about (2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001354-10-4
(2S,4R)-4-methoxypyrrolidine-2-carboxylic acid hydrochloride

: 14588-60-4
4-(benzyloxy)-3,5-dimethoxybenzoic acid

: 1609261-17-7
(2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid

Guidance literature:: 4-(benzyloxy)-3,5-dimethoxybenzoic acid; With oxalyl dichloride; In toluene; at 50 ℃; for 1.5h;

(2S,4R)-4-methoxypyrrolidine-2-carboxylic acid hydrochloride; With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 4.5h;

Reference yield:

: 83624-01-5
(2S,4R)-1-(tert-butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid

: 1609261-17-7
(2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 2 h / 0 - 20 °C

2.1: oxalyl dichloride / toluene / 1.5 h / 50 °C

2.2: 4.5 h / 0 - 20 °C

With hydrogenchloride; oxalyl dichloride; In 1,4-dioxane; toluene;

Reference yield:

: 884-35-5
methyl syringate

: 1609261-17-7
(2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-methoxy-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / acetone / 0.5 h / 20 °C

1.2: 8 h / Reflux

2.1: sodium hydroxide; ethanol / 2 h / Reflux

3.1: oxalyl dichloride / toluene / 1.5 h / 50 °C

3.2: 4.5 h / 0 - 20 °C

With oxalyl dichloride; ethanol; potassium carbonate; potassium iodide; sodium hydroxide; In acetone; toluene;