4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

Base Information

Chemical Name:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate
CAS No.:1362688-85-4
Molecular Formula:C₃₄H₄₃N₆O₉P
Molecular Weight:710.724
Hs Code.:

Synonyms:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

There total 4 articles about 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₅₁N₆O₁₁P

: 1362688-85-4
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

Guidance literature:: C₃₉H₅₁N₆O₁₁P; With phosphoric acid; In chloroform; water; at 20 ℃; for 4.5h;

With water; sodium hydroxide; at 0 - 5 ℃; pH=7;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1362688-85-4
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 22410-97-5
(RS)-2-(4-benzoylphenyl)propanoic acid

: 1362688-85-4
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-benzoylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-valinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013