2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Base Information

Chemical Name:2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile
CAS No.:1448419-13-3
Molecular Formula:C₂₃H₂₁ClN₄O₂
Molecular Weight:420.898
Hs Code.:

Synonyms:2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

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Chemical Property of 2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

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Technology Process of 2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

There total 6 articles about 2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1448419-29-1
2-acetyl-10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]-naphthyridine-8-carbonitrile

: 41965-95-1
(3-chloro-4-methoxyphenyl)methylamine hydrogen chloride

: 1448419-13-3
2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Guidance literature:: With triethylamine; sodium iodide; In 1-methyl-pyrrolidin-2-one; at 130 ℃;

Reference yield:

: 99767-45-0
2-amino-5-cyanobenzoic acid

: 1448419-13-3
2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 6 h / 60 °C

2: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 2 h / 0 °C / Reflux

3: dichloromethane / 1 h / 0 - 20 °C

4: triethylamine; sodium iodide / 1-methyl-pyrrolidin-2-one / 130 °C

With carbonochloridic acid 1-chloro-ethyl ester; triethylamine; sodium iodide; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 1448419-13-3
2-acetyl-10-[(3-chloro-4-methoxybenzyl)amino]-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: iron(III) chloride; hydrogenchloride / 1-methyl-pyrrolidin-2-one; water / 1 h / 60 °C / Reflux

2: trichlorophosphate / 6 h / 60 °C

3: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 2 h / 0 °C / Reflux

4: dichloromethane / 1 h / 0 - 20 °C

5: triethylamine; sodium iodide / 1-methyl-pyrrolidin-2-one / 130 °C

With hydrogenchloride; iron(III) chloride; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; sodium iodide; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; 1,2-dichloro-ethane;