dimethyl (biphenyl-4,40-diylbis{1,3-thiazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(2S)-1-oxobutane-1,2-diyl]})biscarbamate

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Chemical Name:dimethyl (biphenyl-4,40-diylbis{1,3-thiazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(2S)-1-oxobutane-1,2-diyl]})biscarbamate
CAS No.:1310695-64-7
Molecular Formula:C₃₈H₄₄N₆O₆S₂
Molecular Weight:744.936
Hs Code.:

Synonyms:dimethyl (biphenyl-4,40-diylbis{1,3-thiazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(2S)-1-oxobutane-1,2-diyl]})biscarbamate

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Chemical Property of dimethyl (biphenyl-4,40-diylbis{1,3-thiazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(2S)-1-oxobutane-1,2-diyl]})biscarbamate

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Technology Process of dimethyl (biphenyl-4,40-diylbis{1,3-thiazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(2S)-1-oxobutane-1,2-diyl]})biscarbamate

There total 8 articles about dimethyl (biphenyl-4,40-diylbis{1,3-thiazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(2S)-1-oxobutane-1,2-diyl]})biscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1282563-99-8
5,5'-biphenyl-4,4'-diylbis{2-[(2S)-pyrrolidin-2-yl]-1,3-thiazole}

: 259874-14-1
(S)-2-(methoxycarbonylamino)butanoic acid

: 1310695-64-7
dimethyl (biphenyl-4,40-diylbis{1,3-thiazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(2S)-1-oxobutane-1,2-diyl]})biscarbamate

Guidance literature:: (S)-2-(methoxycarbonylamino)butanoic acid; With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

5,5'-biphenyl-4,4'-diylbis{2-[(2S)-pyrrolidin-2-yl]-1,3-thiazole}; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.ejmech.2019.02.016

Reference yield:

: 1256384-71-0
tert-butyl (2S)-2-[5-(4-bromophenyl)-1,3-thiazol-2-yl]pyrrolidine-1-carboxylate

: 1310695-64-7
dimethyl (biphenyl-4,40-diylbis{1,3-thiazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(2S)-1-oxobutane-1,2-diyl]})biscarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 0.5 h / 20 °C

3.3: 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; benzotriazol-1-ol; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2019.02.016

Reference yield:

: 1007881-98-2
y

: 1310695-64-7
dimethyl (biphenyl-4,40-diylbis{1,3-thiazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(2S)-1-oxobutane-1,2-diyl]})biscarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Lawessons reagent / tetrahydrofuran / 6 h / Reflux

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

4.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 0.5 h / 20 °C

4.3: 20 °C

With Lawessons reagent; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; benzotriazol-1-ol; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2019.02.016