(S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate
• CAS No.: 1007881-98-2
• Molecular Formula: C18H23BrN2O4
• Molecular Weight: 411.296
• Mol file: 1007881-98-2.mol

Synonyms:1-Pyrrolidinecarboxylic acid, 2-[[[2-(4-bromophenyl)-2-oxoethyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-;

Chemical Property of (S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate

Chemical Property:

• PSA: 75.71000
• LogP: 3.47630
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate

There total 4 articles about (S)-tert-butyl 2-(5-(4-broMophenyl)-1h-iMidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(S)-N-(tert-butoxycarbonyl)proline methyl ester (59936-29-7) + α-amino-4-bromoacetophenone hydrochloride (5467-72-1) → y (1007881-98-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 0 ℃;

Reference yield: 90.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + α-amino-4-bromoacetophenone hydrochloride (5467-72-1) → y (1007881-98-2)

Guidance literature:

1-(tert-butoxycarbonyl)-L-proline; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 0.5h;

α-amino-4-bromoacetophenone hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield: 62.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + 4-bromophenacylamine (7644-04-4) → y (1007881-98-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 5 ℃; for 1.5h;

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

α-amino-4-bromoacetophenone hydrochloride

4-bromophenacylamine

para-bromophenacyl bromide

Downstream raw materials:

(S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

(S)-tert-butyl 2-(5-(4-bromophenyl)oxazol-2-yl)pyrrolidine-1-carboxylate

tert-butyl (2S)-2-[5-(4-bromophenyl)-1,3-thiazol-2-yl]pyrrolidine-1-carboxylate

((S)-1-{(S)-2-[5-(4-bromophenyl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester