Technology Process of 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide
There total 5 articles about 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-nitro-4-(3-trifluoromethylpyridin-2-yl)benzoic acid;
With
thionyl chloride;
for 4h;
Heating / reflux;
With
ammonia;
In
dichloromethane;
for 0.5h;
Cooling with ice-water bath;
at 20 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / tetrakis-(triphenylphosphino)-palladium(0) / 1,2-dimethoxyethane / 12 h / 80 °C
2.1: nitric acid / sulfuric acid / 1 h / 20 °C
3.1: potassium permanganate / pyridine; water / 4 h / 110 °C
3.2: 12 h / 110 °C
4.1: thionyl chloride / 4 h / Heating / reflux
4.2: 0.5 h / Cooling with ice-water bath
4.3: 0.25 h / 20 °C
With
potassium permanganate; thionyl chloride; nitric acid; sodium carbonate;
tetrakis-(triphenylphosphino)-palladium(0);
In
pyridine; 1,2-dimethoxyethane; sulfuric acid; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / tetrakis-(triphenylphosphino)-palladium(0) / 1,2-dimethoxyethane / 12 h / 80 °C
2.1: nitric acid / sulfuric acid / 1 h / 20 °C
3.1: potassium permanganate / pyridine; water / 4 h / 110 °C
3.2: 12 h / 110 °C
4.1: thionyl chloride / 4 h / Heating / reflux
4.2: 0.5 h / Cooling with ice-water bath
4.3: 0.25 h / 20 °C
With
potassium permanganate; thionyl chloride; nitric acid; sodium carbonate;
tetrakis-(triphenylphosphino)-palladium(0);
In
pyridine; 1,2-dimethoxyethane; sulfuric acid; water;
