N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Base Information

Chemical Name:N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide
CAS No.:717115-87-2
Molecular Formula:C₂₃H₂₁F₃N₂O₂
Molecular Weight:414.427
Hs Code.:

Synonyms:N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

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Chemical Property of N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

There total 8 articles about N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359648-03-5
2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzoic acid

: 769-92-6
4-tert-Butylaniline

: 717115-87-2
N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 6h;

Reference yield:

: 573676-05-8
2-(4-methyl-3-nitrophenyl)-3-(trifluoromethyl)pyridine

: 717115-87-2
N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium permanganate / pyridine; water / 4 h / 110 °C

1.2: 12 h / 110 °C

2.1: thionyl chloride / 4 h / Heating / reflux

2.2: 0.5 h / Cooling with ice-water bath

2.3: 0.25 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h

4.1: sodium nitrite / sulfuric acid; water / 0.25 h / 0 °C

4.2: 4 h / 130 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / DMF (N,N-dimethyl-formamide) / 6 h / 80 °C

With potassium permanganate; thionyl chloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium nitrite; palladium 10% on activated carbon; In pyridine; DMF (N,N-dimethyl-formamide); ethanol; sulfuric acid; water;

Reference yield:

: 573680-40-7
2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

: 717115-87-2
N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h

2.1: sodium nitrite / sulfuric acid; water / 0.25 h / 0 °C

2.2: 4 h / 130 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / DMF (N,N-dimethyl-formamide) / 6 h / 80 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium nitrite; palladium 10% on activated carbon; In DMF (N,N-dimethyl-formamide); ethanol; sulfuric acid; water;