N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Base Information

• Chemical Name: N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide
• CAS No.: 717115-87-2
• Molecular Formula: C₂₃H₂₁F₃N₂O₂
• Molecular Weight: 414.427
• Mol file: 717115-87-2.mol

Synonyms:N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Chemical Property of N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

There total 8 articles about N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzoic acid (1359648-03-5) + 4-tert-Butylaniline (769-92-6) → N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide (717115-87-2)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 6h;

Reference yield:

2-(4-methyl-3-nitrophenyl)-3-(trifluoromethyl)pyridine (573676-05-8) → N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide (717115-87-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium permanganate / pyridine; water / 4 h / 110 °C

1.2: 12 h / 110 °C

2.1: thionyl chloride / 4 h / Heating / reflux

2.2: 0.5 h / Cooling with ice-water bath

2.3: 0.25 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h

4.1: sodium nitrite / sulfuric acid; water / 0.25 h / 0 °C

4.2: 4 h / 130 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / DMF (N,N-dimethyl-formamide) / 6 h / 80 °C

With potassium permanganate; thionyl chloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium nitrite; palladium 10% on activated carbon; In pyridine; DMF (N,N-dimethyl-formamide); ethanol; sulfuric acid; water;

Reference yield:

2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide (573680-40-7) → N-(4-tert-butyl-phenyl)-2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide (717115-87-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h

2.1: sodium nitrite / sulfuric acid; water / 0.25 h / 0 °C

2.2: 4 h / 130 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / DMF (N,N-dimethyl-formamide) / 6 h / 80 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium nitrite; palladium 10% on activated carbon; In DMF (N,N-dimethyl-formamide); ethanol; sulfuric acid; water;

upstream raw materials:

2-hydroxy-4-(3-trifluoromethyl-pyridin-2-yl)-benzoic acid

4-tert-Butylaniline

2-(p-tolyl)-3-(trifluoromethyl)pyridine

2-(4-methyl-3-nitrophenyl)-3-(trifluoromethyl)pyridine