methyl 5-bromo-3-((cyclopropylmethyl)(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate

Base Information

Chemical Name:methyl 5-bromo-3-((cyclopropylmethyl)(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate
CAS No.:1403258-02-5
Molecular Formula:C₁₈H₂₄BrNO₃
Molecular Weight:382.297
Hs Code.:

Synonyms:methyl 5-bromo-3-((cyclopropylmethyl)(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate

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Chemical Property of methyl 5-bromo-3-((cyclopropylmethyl)(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate

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Technology Process of methyl 5-bromo-3-((cyclopropylmethyl)(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate

There total 6 articles about methyl 5-bromo-3-((cyclopropylmethyl)(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.7%

: 1403257-49-7
2-methyl-3[(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1403258-02-5
methyl 5-bromo-3-((cyclopropylmethyl)(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate

Guidance literature:: 2-methyl-3[(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester; Cyclopropanecarboxaldehyde; With acetic acid; In methanol; at 20 ℃; for 8h;

With methanol; sodium cyanoborohydride; at 0 - 20 ℃;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403258-02-5
methyl 5-bromo-3-((cyclopropylmethyl)(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

3.1: acetic acid / 1,1-dichloroethane / 0.25 h / 20 °C

3.2: 0 - 20 °C

4.1: acetic acid / methanol / 8 h / 20 °C

4.2: 0 - 20 °C

With iron; sodium carbonate; ammonium chloride; acetic acid; In methanol; 1,1-dichloroethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1403258-02-5
methyl 5-bromo-3-((cyclopropylmethyl)(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 5 h / 20 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

4.1: acetic acid / 1,1-dichloroethane / 0.25 h / 20 °C

4.2: 0 - 20 °C

5.1: acetic acid / methanol / 8 h / 20 °C

5.2: 0 - 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; iron; sodium carbonate; ammonium chloride; acetic acid; In methanol; 1,1-dichloroethane; ethanol; water; N,N-dimethyl-formamide;