8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine

Base Information

Chemical Name:8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine
CAS No.:1415830-02-2
Molecular Formula:C₁₈H₁₂ClN₃O
Molecular Weight:321.766
Hs Code.:

Synonyms:8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine

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Chemical Property of 8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine

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Technology Process of 8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine

There total 6 articles about 8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94402-42-3
2-bromo-1-(2-phenoxyphenyl)ethan-1-one

: 1415830-02-2
8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide / dimethyl sulfoxide / 20 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; methanol / methanol / 1 h / Inert atmosphere; Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / methanol

4.1: triethylamine / 1,4-dioxane / 17 h / Reflux; Inert atmosphere

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C

5.2: 2.5 h / -78 - 20 °C

6.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 69 h / 20 °C / Cooling with ice

With methanol; sodium tetrahydroborate; sodium azide; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 1415829-93-4
2-azido-1-(2-phenoxyphenyl)ethanone

: 1415830-02-2
8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; methanol / methanol / 1 h / Inert atmosphere; Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol

3.1: triethylamine / 1,4-dioxane / 17 h / Reflux; Inert atmosphere

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C

4.2: 2.5 h / -78 - 20 °C

5.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 69 h / 20 °C / Cooling with ice

With methanol; sodium tetrahydroborate; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; toluene;

Reference yield:

: 26388-13-6
1-(2-phenoxyphenyl)ethan-1-one

: 1415830-02-2
8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridinium hydrobromide perbromide / chloroform; ethanol / 16 h / 50 °C

2.1: sodium azide / dimethyl sulfoxide / 20 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / methanol / 1 h / Inert atmosphere; Cooling with ice

4.1: hydrogen / palladium 10% on activated carbon / methanol

5.1: triethylamine / 1,4-dioxane / 17 h / Reflux; Inert atmosphere

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C

6.2: 2.5 h / -78 - 20 °C

7.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 69 h / 20 °C / Cooling with ice

With methanol; sodium tetrahydroborate; sodium azide; oxalyl dichloride; hydrogen; pyridinium hydrobromide perbromide; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; toluene;