4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide
CAS No.:1415829-36-5
Molecular Formula:C₂₅H₂₀N₄O₃S
Molecular Weight:456.525
Hs Code.:

Synonyms:4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

Suppliers and Price of 4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

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Technology Process of 4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

There total 8 articles about 4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1415830-02-2
8-chloro-3-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine

: 70-55-3
toluene-4-sulfonamide

: 1415829-36-5
4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

Guidance literature:: With potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In tert-butyl alcohol; for 40h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2014.09.036

Reference yield:

: 94402-42-3
2-bromo-1-(2-phenoxyphenyl)ethan-1-one

: 1415829-36-5
4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium azide / dimethyl sulfoxide / 20 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; methanol / methanol / 1 h / Inert atmosphere; Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / methanol

4.1: triethylamine / 1,4-dioxane / 17 h / Reflux; Inert atmosphere

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C

5.2: 2.5 h / -78 - 20 °C

6.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 69 h / 20 °C / Cooling with ice

7.1: potassium carbonate; tert-butyl alcohol / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos / 40 h / Inert atmosphere; Reflux

With methanol; sodium tetrahydroborate; sodium azide; oxalyl dichloride; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; tert-butyl alcohol; palladium 10% on activated carbon; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 1415829-93-4
2-azido-1-(2-phenoxyphenyl)ethanone

: 1415829-36-5
4-methyl-N-[2-(phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate; methanol / methanol / 1 h / Inert atmosphere; Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol

3.1: triethylamine / 1,4-dioxane / 17 h / Reflux; Inert atmosphere

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C

4.2: 2.5 h / -78 - 20 °C

5.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 69 h / 20 °C / Cooling with ice

6.1: potassium carbonate; tert-butyl alcohol / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos / 40 h / Inert atmosphere; Reflux

With methanol; sodium tetrahydroborate; oxalyl dichloride; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; tert-butyl alcohol; palladium 10% on activated carbon; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; methanol; dichloromethane; toluene;