2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3H-pyrimidin-4-one

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Chemical Name:2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3H-pyrimidin-4-one
CAS No.:833480-26-5
Molecular Formula:C₃₆H₄₅N₅O₈Si
Molecular Weight:703.867
Hs Code.:

2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3<i>H</i>-pyrimidin-4-one

Synonyms:2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3H-pyrimidin-4-one

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Chemical Property of 2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3H-pyrimidin-4-one

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Technology Process of 2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3H-pyrimidin-4-one

There total 2 articles about 2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1007-99-4
2-amino-4-chloro-6-hydroxy-5-nitropyrimidine

: 418759-83-8
(4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine

: 833480-26-5
2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3H-pyrimidin-4-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 70 ℃; for 14h;
DOI:10.1021/jo048253o

Reference yield:

: 833480-25-4
{(2R,3S)-5-Azido-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yloxy}-tert-butyl-dimethyl-silane

: 833480-26-5
2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Lindlar's catalyst / ethanol / 1.25 h / 2327.17 Torr

2: 43 percent / diisopropylethylamine / ethanol / 14 h / 70 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; Lindlar's catalyst; In ethanol;
DOI:10.1021/jo048253o

Reference yield:

: 833480-26-5
2-amino-6-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamino]-5-nitro-3H-pyrimidin-4-one

: 833480-34-5
C₅₃H₆₀N₇O₁₆P

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylethylamine; PyBOP / CH₂Cl₂ / 0 - 25 °C

2.1: 12 percent / FeCl₃*6H₂O / acetonitrile / 1.5 h / 25 °C

3.1: tetrazole / acetonitrile / 0 - 25 °C

3.2: 47 percent / tert-butyl hydroperoxide / acetonitrile; decane / 0.5 h / 0 °C

4.1: H₂; diisopropylethylamine / Pd/C / tetrahydrofuran / 2 h / 25 °C / 4137.18 Torr

4.2: 6 percent / pyridine / tetrahydrofuran / 0.17 h / 0 °C

5.1: 83 percent / Bu₄NF*3H₂O; acetic acid / tetrahydrofuran / 5 h / 0 °C

With 1H-tetrazole; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; iron(III) chloride; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo048253o