4-(3,5-difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide

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Chemical Name:4-(3,5-difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide
CAS No.:1309921-07-0
Molecular Formula:C₂₇H₁₇ClF₂N₄O
Molecular Weight:486.908
Hs Code.:

Synonyms:4-(3,5-difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide

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Chemical Property of 4-(3,5-difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide

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Technology Process of 4-(3,5-difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide

There total 4 articles about 4-(3,5-difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1309921-15-0
4-bromo-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolinamide

: 156545-07-2
3,5-difluorophenylboronic acid

: 1309921-07-0
4-(3,5-difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; sodium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.12.110

Reference yield:

: 100-47-0
benzonitrile

: 1309921-07-0
4-(3,5-difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / benzene

2: hydrogenchloride / water

3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; sodium carbonate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; potassium tert-butylate; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; water; benzene; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.110

Reference yield:

: 1823-99-0,17196-74-6,60375-56-6
3-amino-3-phenylacrylonitrile

: 1309921-07-0
4-(3,5-difluorophenyl)-N-(1-[2-chlorophenyl]-3-phenyl-1H-pyrazol-5-yl)picolin-amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; sodium carbonate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; water; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.110