methyl 2-((2S,6R)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-4-oxo-2H-pyran-2-yl)acetate

Base Information

Chemical Name:methyl 2-((2S,6R)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-4-oxo-2H-pyran-2-yl)acetate
CAS No.:1273019-38-7
Molecular Formula:C₂₁H₃₀O₆
Molecular Weight:378.466
Hs Code.:

Synonyms:methyl 2-((2S,6R)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-4-oxo-2H-pyran-2-yl)acetate

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Chemical Property of methyl 2-((2S,6R)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-4-oxo-2H-pyran-2-yl)acetate

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Technology Process of methyl 2-((2S,6R)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-4-oxo-2H-pyran-2-yl)acetate

There total 10 articles about methyl 2-((2S,6R)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-4-oxo-2H-pyran-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1273019-41-2
methyl 2-((2S,4R,6S)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-4-hydroxy-3,3-dimethyl-2H-pyran-2-yl)acetate

: 1273019-38-7
methyl 2-((2S,6R)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-4-oxo-2H-pyran-2-yl)acetate

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1039/c0ob00971g

Reference yield:

: (S)-1-((4R,6R)-2,2-dimethyl-6-(2-methylbut-3-en-2-yl)-1,3-dioxan-4-yl)butan-2-yl propionate

: 1273019-38-7
methyl 2-((2S,6R)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-4-oxo-2H-pyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

3: hydrogenchloride / methanol; water / 0 °C

4: copper dichloride; palladium dichloride / acetonitrile / 12 h / 30 °C

5: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; sodium hydrogencarbonate; Dess-Martin periodane; triphenylphosphine; copper dichloride; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 2: Mitsunobu reaction;
DOI:10.1039/c0ob00971g

Reference yield:

: (4R,6R)-4-((R)-2-(4-methoxyphenoxy)butyl)-2,2-dimethyl-6-(2-methylbut-3-en-2-yl)-1,3-dioxane

: 1273019-38-7
methyl 2-((2S,6R)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-4-oxo-2H-pyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol; water / 0 °C

2: copper dichloride; palladium dichloride / acetonitrile / 12 h / 30 °C

3: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; Dess-Martin periodane; copper dichloride; palladium dichloride; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1039/c0ob00971g