methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

Base Information

Chemical Name:methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate
CAS No.:1273019-39-8
Molecular Formula:C₂₉H₄₆O₁₀
Molecular Weight:554.678
Hs Code.:

methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

Synonyms:methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

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Chemical Property of methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

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Technology Process of methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

There total 17 articles about methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 870096-05-2
(2S,3R,4S,5R)-3,4,5-trimethoxy-2-(phenylthio)tetrahydro-2H-pyran

: 1273019-29-6
methyl 2-((2S,4S,6S)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-4-hydroxy-3,3-dimethyl-2H-pyran-2-yl)acetate

: 1273019-39-8
methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

: methyl 2-((2S,4S,6R)-4-((2R,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

Guidance literature:: With methyl trifluoromethanesulfonate; In diethyl ether; at 25 ℃; for 48h; optical yield given as %de; Molecular sieve; Inert atmosphere;
DOI:10.1039/c0ob00971g

Reference yield:

: 1273019-31-0
(3S,5S)-5-hydroxyoct-7-en-3-yl propionate

: 1273019-39-8
methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

: methyl 2-((2S,4S,6R)-4-((2R,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1: oxygen; ozone; triphenylphosphine / dichloromethane / 4 h / -78 - 20 °C

2: ammonium chloride; zinc / tetrahydrofuran; water / 0 - 20 °C

3: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 0 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

6: hydrogenchloride / methanol; water / 2 h / 0 °C

7: copper dichloride; palladium dichloride / acetonitrile / 12 h / 30 °C

8: methyl trifluoromethanesulfonate / diethyl ether / 48 h / 25 °C / Molecular sieve; Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; oxygen; ammonium chloride; toluene-4-sulfonic acid; ozone; triphenylphosphine; methyl trifluoromethanesulfonate; copper dichloride; palladium dichloride; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile; 2: Barbier type reaction / 5: Mitsunobu reaction;
DOI:10.1039/c0ob00971g

Reference yield:

: 1273019-32-1
(S)-1-(2-allyl-1,3-dithian-2-yl)butan-2-ol

: 1273019-39-8
methyl 2-((2S,4S,6R)-4-((2S,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

: methyl 2-((2S,4S,6R)-4-((2R,3R,4S,5R)-tetrahydro-3,4,5-trimethoxy-2H-pyran-2-yloxy)-6-((R)-2-(4-methoxyphenoxy)butyl)-tetrahydro-3,3-dimethyl-2H-pyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 10 steps

1: water; iodine; calcium carbonate / tetrahydrofuran / 0.5 h / 0 °C

2: samarium diiodide / tetrahydrofuran / -10 °C / Inert atmosphere

3: oxygen; ozone; triphenylphosphine / dichloromethane / 4 h / -78 - 20 °C

4: ammonium chloride; zinc / tetrahydrofuran; water / 0 - 20 °C

5: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 0 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

7: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

8: hydrogenchloride / methanol; water / 2 h / 0 °C

9: copper dichloride; palladium dichloride / acetonitrile / 12 h / 30 °C

10: methyl trifluoromethanesulfonate / diethyl ether / 48 h / 25 °C / Molecular sieve; Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; samarium diiodide; di-isopropyl azodicarboxylate; water; iodine; oxygen; ammonium chloride; toluene-4-sulfonic acid; ozone; triphenylphosphine; methyl trifluoromethanesulfonate; calcium carbonate; copper dichloride; palladium dichloride; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile; 2: Evans-Tishchenko reduction / 4: Barbier type reaction / 7: Mitsunobu reaction;
DOI:10.1039/c0ob00971g