(1'R,2'S,3'R)-N³-benzoyl-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorouracil

Base Information

• Chemical Name: (1'R,2'S,3'R)-N³-benzoyl-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorouracil
• CAS No.: 377748-91-9
• Molecular Formula: C₂₄H₂₇FN₂O₆
• Molecular Weight: 458.487

Synonyms:(1'R,2'S,3'R)-N³-benzoyl-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorouracil

Chemical Property of (1'R,2'S,3'R)-N³-benzoyl-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorouracil

Chemical Property:

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Technology Process of (1'R,2'S,3'R)-N³-benzoyl-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorouracil

There total 5 articles about (1'R,2'S,3'R)-N³-benzoyl-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzoyl-5-fluorouracil (61251-77-2) + (1S,2R,3R)-1-acetoxy-2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten (377748-59-9) → (1'R,2'S,3'R)-N3-benzoyl-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorouracil (377748-91-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm010256v

Reference yield:

tert-butyl methyl ether (1634-04-4) → (1'R,2'S,3'R)-N3-benzoyl-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorouracil (377748-91-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: t-BuOK; sec-BuLi / hexane / 3.5 h / -70 °C

1.2: tetrahydrofuran; hexane / 3 h / -70 °C

2.1: DMAP; Et₃N / CH₂Cl₂ / 24 h / 20 °C

3.1: PdCl₂(CH₃CN)2; p-benzoquinone / tetrahydrofuran / 24 h / Heating

4.1: diethyl azadicarboxylate (DEAD); PPh₃ / tetrahydrofuran / 16 h / 20 °C

With dmap; dichloro bis(acetonitrile) palladium(II); potassium tert-butylate; sec.-butyllithium; triethylamine; triphenylphosphine; p-benzoquinone; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm010256v

Reference yield:

(3aS,6aS)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one (104010-72-2) → (1'R,2'S,3'R)-N3-benzoyl-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorouracil (377748-91-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: t-BuOK; sec-BuLi / hexane / 3.5 h / -70 °C

1.2: tetrahydrofuran; hexane / 3 h / -70 °C

2.1: DMAP; Et₃N / CH₂Cl₂ / 24 h / 20 °C

3.1: PdCl₂(CH₃CN)2; p-benzoquinone / tetrahydrofuran / 24 h / Heating

4.1: diethyl azadicarboxylate (DEAD); PPh₃ / tetrahydrofuran / 16 h / 20 °C

With dmap; dichloro bis(acetonitrile) palladium(II); potassium tert-butylate; sec.-butyllithium; triethylamine; triphenylphosphine; p-benzoquinone; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm010256v

upstream raw materials:

3-benzoyl-5-fluorouracil

(1S,2R,3R)-1-acetoxy-2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten

tert-butyl methyl ether

(3aS,6aS)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one

Downstream raw materials:

(1'R,2'S,3'R)-1-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]-5-fluorocytosine

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