61251-77-2Relevant articles and documents
Automated modular synthesis of Aptamer-drug conjugates for targeted drug delivery
Wang, Ruowen,Zhu, Guizhi,Mei, Lei,Xie, Yan,Ma, Haibin,Ye, Mao,Qing, Feng-Ling,Tan, Weihong
supporting information, p. 2731 - 2734 (2014/03/21)
Aptamer-drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low control
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates
Topalis, Dimitri,Pradère, Ugo,Roy, Vincent,Caillat, Christophe,Azzouzi, Ahmed,Broggi, Julie,Snoeck, Robert,Andrei, Graciela,Lin, Jay,Eriksson, Staffan,Alexandre, Julie A. C.,El-Amri, Chahrazade,Deville-Bonne, Dominique,Meyer, Philippe,Balzarini, Jan,Agrofoglio, Luigi A.
scheme or table, p. 222 - 232 (2011/03/22)
Acyclic nucleoside phosphonates (ANPs) are at the cornerstone of DNA virus and retrovirus therapies. They reach their target, the viral DNA polymerase, after two phosphorylation steps catalyzed by cellular kinases. New pyrimidine ANPs have been synthesize
Synthesis of 1- and 3-Arylcarbonyl Derivatives of 5-Fluorouracil
Perrin, John H.,Underberg, William J.,Sloan, Kenneth B.
, p. 397 - 402 (2007/10/03)
4'-Substituted 1-arylcarbonyl-5-fluorouracil derivatives were synthesized from the reaction of the potassium salt of 5-fluorouracil with one equivalent of aryl acid chloride in acetonitrile. 4'-Substituted 3-arylcarbonyl-5-fluorouracil derivatives were sy
