6-(3-benzyloxy-2-hydroxypropyl)-5-methyl-1-[(2-trimethylsilyl)ethoxymethyl]pyrimidin-2,4-dione

Base Information

Chemical Name:6-(3-benzyloxy-2-hydroxypropyl)-5-methyl-1-[(2-trimethylsilyl)ethoxymethyl]pyrimidin-2,4-dione
CAS No.:1613134-69-2
Molecular Formula:C₂₁H₃₂N₂O₅Si
Molecular Weight:420.581
Hs Code.:

Synonyms:6-(3-benzyloxy-2-hydroxypropyl)-5-methyl-1-[(2-trimethylsilyl)ethoxymethyl]pyrimidin-2,4-dione

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Chemical Property of 6-(3-benzyloxy-2-hydroxypropyl)-5-methyl-1-[(2-trimethylsilyl)ethoxymethyl]pyrimidin-2,4-dione

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Technology Process of 6-(3-benzyloxy-2-hydroxypropyl)-5-methyl-1-[(2-trimethylsilyl)ethoxymethyl]pyrimidin-2,4-dione

There total 3 articles about 6-(3-benzyloxy-2-hydroxypropyl)-5-methyl-1-[(2-trimethylsilyl)ethoxymethyl]pyrimidin-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1613134-66-9
6-(3-benzyloxy-2-hydroxypropyl)-5-methylpyrimidin-2,4-dione

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1613134-69-2
6-(3-benzyloxy-2-hydroxypropyl)-5-methyl-1-[(2-trimethylsilyl)ethoxymethyl]pyrimidin-2,4-dione

Guidance literature:: 6-(3-benzyloxy-2-hydroxypropyl)-5-methylpyrimidin-2,4-dione; With ammonium bisulphate; 1,1,1,3,3,3-hexamethyl-disilazane; for 2h; Reflux;

(2-trimethylethylsilylethoxy)methyl chloride; at -5 - 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2014.04.079

Reference yield:

: 856766-74-0
6-(3-benzyloxy-2-hydroxypropyl)-2,4-dimethoxy-5-methylpyrimidine

: 1613134-69-2
6-(3-benzyloxy-2-hydroxypropyl)-5-methyl-1-[(2-trimethylsilyl)ethoxymethyl]pyrimidin-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 18 h / 20 °C

2.1: ammonium bisulphate; 1,1,1,3,3,3-hexamethyl-disilazane / 2 h / Reflux

2.2: 24 h / -5 - 20 °C

With ammonium bisulphate; chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; sodium iodide; In acetonitrile;
DOI:10.1016/j.bmcl.2014.04.079

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 1613134-69-2
6-(3-benzyloxy-2-hydroxypropyl)-5-methyl-1-[(2-trimethylsilyl)ethoxymethyl]pyrimidin-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -70 - -55 °C / Inert atmosphere

1.2: 12 h / -55 °C / Inert atmosphere

2.1: acetyl chloride / 5 h / Reflux

3.1: ammonium bisulphate; 1,1,1,3,3,3-hexamethyl-disilazane / 2 h / Reflux

3.2: 24 h / -5 - 20 °C

With ammonium bisulphate; acetyl chloride; 1,1,1,3,3,3-hexamethyl-disilazane; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2014.04.079