856766-74-0Relevant academic research and scientific papers
Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives
Gazivoda Kraljevi?, Tatjana,Ili?, Nata?a,Stepani?, Vi?nja,Sappe, Lana,Petranovi?, Jasna,Kraljevi? Paveli?, Sandra,Rai?-Mali?, Silvana
supporting information, p. 2913 - 2917 (2014/06/10)
A series of novel N-alkylated C-6-isobutyl- or -propyl pyrimidine derivatives were synthesized and their antiproliferative effect was evaluated on a panel of tumor cell lines including leukemia cell line K562 and normal diploid human fibroblasts. N-methox
Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues
Raic-Malic, Silvana,Johayem, Anass,Ametamey, Simon M.,Batinac, Sanja,De Clercq, Erik,Folkers, Gerd,Scapozza, Leonardo
, p. 1707 - 1721 (2007/10/03)
Synthesis of pyrimidine derivatives with a side-chain attached to the C-6 of pyrimidine ring (6-14) is reported. Target compounds 8 and 12 were subjected to in vitro phosphorylation tests, determination of their binding affinities to herpes simplex virus
