(R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one

Base Information

Chemical Name:(R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one
CAS No.:219123-54-3
Molecular Formula:C₄₅H₇₂F₂O₄SSi₂
Molecular Weight:803.298
Hs Code.:

(R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one

Synonyms:(R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one

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Chemical Property of (R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one

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Technology Process of (R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one

There total 1 articles about (R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1519-39-7
(R)-methyl p-tolyl sulfoxide

: 143884-27-9
(R)-5-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2,2-difluoro-hexanoic acid methyl ester

: 219123-54-3
(R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; 1.) -78 deg C, 15 min, 2.) room temp., 1.5 h;
DOI:10.1016/S0040-4020(98)00949-1

Reference yield:

: 219123-54-3
(R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one

: 197702-98-0
(2S,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) ZnBr₂ / 1.) CH₂Cl₂, room temp., 30 min, 2.) CH₂Cl₂, hexane, -78 deg C, 3 h

2: 76 percent / NaH / tetrahydrofuran / 2 h / 0 °C

3: 1.) trifluoroacetic anhydride, pyridine, 2.) aq. KOH / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₃CN, CH₂Cl₂, 0 deg C, 2 h

4: 95 percent / NaBH₄ / methanol / 0.5 h / 0 °C

With pyridine; potassium hydroxide; sodium tetrahydroborate; sodium hydride; trifluoroacetic anhydride; zinc dibromide; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(98)00949-1

Reference yield:

: 219123-54-3
(R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-1-((R)-toluene-4-sulfinyl)-heptan-2-one

: 197702-96-8
(2S,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-3,3-difluoro-2-(2-methoxy-ethoxymethoxy)-2-methyl-heptanal

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ZnBr₂ / 1.) CH₂Cl₂, room temp., 30 min, 2.) CH₂Cl₂, hexane, -78 deg C, 3 h

2: 76 percent / NaH / tetrahydrofuran / 2 h / 0 °C

3: 1.) trifluoroacetic anhydride, pyridine, 2.) aq. KOH / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₃CN, CH₂Cl₂, 0 deg C, 2 h

With pyridine; potassium hydroxide; sodium hydride; trifluoroacetic anhydride; zinc dibromide; In tetrahydrofuran;
DOI:10.1016/S0040-4020(98)00949-1