(2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine

Base Information

Chemical Name:(2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine
CAS No.:249284-74-0
Molecular Formula:C₂₉H₃₅NO₅S
Molecular Weight:509.667
Hs Code.:

Synonyms:(2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine

Suppliers and Price of (2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine

Chemical Property:

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Technology Process of (2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine

There total 4 articles about (2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 219715-78-3
(R)-N-[1'-(2-Furyl)-2'-benzyloxyethyl]toluene-p-sulfonamide

: 249284-74-0
(2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / m-CPBA / CH₂Cl₂ / 16 h / Ambient temperature

2: 97 percent / BF₃*Et₂O, 4A molecular sieves / tetrahydrofuran / 4 h / 0 °C

3: 88 percent / NaBH₄ / methanol / 3 h / 0 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 2 h

With sodium tetrahydroborate; 4 A molecular sieve; boron trifluoride diethyl etherate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(99)00239-6

Reference yield:

: 249284-70-6
(2R,6S)-1,6-dihydro-1-tosyl-6-hydroxy-2-phenylmethoxymethyl-3(2H)-pyridinone

: 249284-74-0
(2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / BF₃*Et₂O, 4A molecular sieves / tetrahydrofuran / 4 h / 0 °C

2: 88 percent / NaBH₄ / methanol / 3 h / 0 °C

3: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 2 h

With sodium tetrahydroborate; 4 A molecular sieve; boron trifluoride diethyl etherate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/S0957-4166(99)00239-6

Reference yield:

: 249284-71-7
(2R,6S)-1,6-dihydro-1-tosyl-6-ethoxy-2-phenylmethoxymethyl-3(2H)-pyridinone

: 249284-74-0
(2R,3S,6S)-1-tosyl-3-phenylmethoxy-6-ethyloxy-2-phenylmethoxymethylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NaBH₄ / methanol / 3 h / 0 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 2 h

With sodium tetrahydroborate; sodium hydride; In methanol;
DOI:10.1016/S0957-4166(99)00239-6