219715-78-3Relevant academic research and scientific papers
Chirally templated boronic acid Mannich reaction in the synthesis of optically active α-amino acids
Currie, Gordon S.,Drew, Michael G.B.,Harwood, Laurence M.,Hughes, David J.,Luke, Richard W.A.,Vickers, Richard J.
, p. 2982 - 2990 (2007/10/03)
Adducts from diastereoselective Mannich-type reactions of aldehydes, 2-furylboronic acid and the chiral amine template (S)-5-phenylmorpholin-2-one, were used in the synthesis of a series of enantiomerically pure D-α-amino acids. The direction of diastereocontrol was proved by X-ray crystallography analysis of the reaction products. Results indicated that sequential degradation of diastereomically pure N-furfurylmorpholinones obtained by boronic Mannich condensation, could be carried out to produce amino acids of high optical purity.
A new concise stereoselective method for the preparation of a β- hydroxyfurfurylamine derivative and synthesis of 1-deoxyazasugar isomers
Liao, Li-Xin,Wang, Zhi-Min,Zhang, Hong-Xing,Zhou, Wei-Shan
, p. 3649 - 3657 (2007/10/03)
A new method to prepare a chiral building block, a β- hydroxyfurfurylamine derivative, is achieved and 1-deoxyazasugar isomers are synthesized.
