(-)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

Base Information

Chemical Name:(-)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide
CAS No.:678991-38-3
Molecular Formula:C₂₉H₃₆N₂O₂
Molecular Weight:444.617
Hs Code.:

Synonyms:(-)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

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Chemical Property of (-)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

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Technology Process of (-)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

There total 3 articles about (-)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-49-1
dibenzylamine

: 678991-33-8
E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pent-2-enamide

: 678991-38-3
(-)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

: (3S)-3-(dibenzylamino)-N-methyl-N-[(1S,2S)-2-phenyl-2-hydroxy-1-methylethyl]pentanamide

Guidance literature:: With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In toluene; at -90 ℃; for 7.5h; Title compound not separated from byproducts;
DOI:10.1021/jo0357768

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 678991-38-3
(-)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Et₃N / tetrahydrofuran / 1.5 h / -20 °C

2: n-BuLi; PMDETA / toluene / -90 °C

With n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jo051207j

Reference yield:

: 33698-85-0
(E)-pent-2-enoyl chloride

: 678991-38-3
(-)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Et₃N / tetrahydrofuran / 1.5 h / -20 °C

2: n-BuLi; PMDETA / toluene / -90 °C

With n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jo051207j