2-Trifluoromethyl-pyridine-3-boronic acid pinacol ester

Base Information

• Chemical Name: 2-Trifluoromethyl-pyridine-3-boronic acid pinacol ester
• CAS No.: 1383625-22-6
• Molecular Formula: C₁₂H₁₅BF₃NO₂
• Molecular Weight: 273.063
• Mol file: 1383625-22-6.mol

Synonyms:3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine

Chemical Property of 2-Trifluoromethyl-pyridine-3-boronic acid pinacol ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-Trifluoromethyl-pyridine-3-boronicacidpinacolester 96% ^*data from reagent suppliers

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Technology Process of 2-Trifluoromethyl-pyridine-3-boronic acid pinacol ester

There total 1 articles about 2-Trifluoromethyl-pyridine-3-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

bis(pinacol)diborane (73183-34-3) + 3-bromo-2-(trifluoromethyl)pyridine (590371-58-7) → 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine (1383625-22-6)

Guidance literature:

3-bromo-2-(trifluoromethyl)pyridine; In 1,4-dioxane; for 0.166667h; Sealed tube; Inert atmosphere;

bis(pinacol)diborane; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield: 60.0%

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine (1383625-22-6) + 6-chloro-2-(4-methyl-3-nitrophenyl)imidazo[2,1-f]pyridazine (1383625-15-7) → 2-(4-methyl-3-nitrophenyl)-6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazine (1383625-20-4)

Guidance literature:

With potassium acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; butan-1-ol; at 90 ℃; for 4h;

Reference yield: 15.0%

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine (1383625-22-6) + 3-bromo-N-alpha-[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-N-[4-(1H-tetrazol-5-yl)phenyl]-L-phenylalaninamide → N-alpha-[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-N-[4-(1H-tetrazol-5-yl)phenyl]-3-[2-(trifluoromethyl)pyridin-3-yl]-L-phenylalaninamide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; dimethyl sulfoxide; at 110 ℃; for 1.5h; Microwave irradiation;

upstream raw materials:

bis(pinacol)diborane

3-bromo-2-(trifluoromethyl)pyridine

Downstream raw materials:

2-(4-methyl-3-nitrophenyl)-6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazine

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