6-Nitroindoline-2-carboxylic acid

Base Information

Chemical Name:6-Nitroindoline-2-carboxylic acid
CAS No.:428861-42-1
Molecular Formula:C₉H₈N₂O₄
Molecular Weight:208.174
Hs Code.:
DSSTox Substance ID:DTXSID60466507
Mol file:428861-42-1.mol

Synonyms:6-nitroindoline-2-carboxylic acid;428861-42-1;6-nitro-2,3-dihydro-1H-indole-2-carboxylic Acid;1H-Indole-2-carboxylicacid,2,3-dihydro-6-nitro-(9CI);SCHEMBL4537304;6-nitroindoline-2-carboxylicacid;DTXSID60466507;NFQWNEJEGYYGON-UHFFFAOYSA-N;AM20040457;FT-0660728;EN300-320709;A846668;1H-Indole-2-carboxylic acid, 2,3-dihydro-6-nitro

Suppliers and Price of 6-Nitroindoline-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 6-Nitroindoline-2-carboxylic acid

Chemical Property:

PSA：95.15000
Density:1.501
LogP:1.67720
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:208.04840674
Heavy Atom Count:15
Complexity:288

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(NC2=C1C=CC(=C2)[N+](=O)[O-])C(=O)O

Technology Process of 6-Nitroindoline-2-carboxylic acid

There total 2 articles about 6-Nitroindoline-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 16851-56-2,78348-24-0
indolin-2-yl carboxylic acid

: 428861-42-1
6-nitroindoline-2-carboxylic acid

: 428861-44-3
5-nitro-indoline-2-carboxylic acid

Guidance literature:: With sulfuric acid; nitric acid; at -20 - -10 ℃; for 0.5h;
DOI:10.1055/s-2002-20043

Reference yield:

: 16851-56-2,78348-24-0
indolin-2-yl carboxylic acid

: 428861-42-1
6-nitroindoline-2-carboxylic acid

Guidance literature:: indolin-2-yl carboxylic acid; With sulfuric acid; nitric acid; at -20 - -10 ℃; for 0.5h;

With sodium hydroxide; In water; pH=4 - 5;

Reference yield:

: 428861-42-1
6-nitroindoline-2-carboxylic acid

: 136818-66-1
6-Nitro-1H-indole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / p-toluenesulfonic acid monohydrate / 0.5 h / Heating

2: 94 percent / DDQ / ethyl acetate; benzene / 0.5 h / Heating

With toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethyl acetate; benzene;
DOI:10.1055/s-2002-20043