1,4,5,6-tetrahydro-6-(4-nitrobenzoyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine

Base Information

Chemical Name:1,4,5,6-tetrahydro-6-(4-nitrobenzoyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine
CAS No.:203636-53-7
Molecular Formula:C₁₇H₁₃N₅O₃
Molecular Weight:335.322
Hs Code.:

Synonyms:1,4,5,6-tetrahydro-6-(4-nitrobenzoyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine

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Chemical Property of 1,4,5,6-tetrahydro-6-(4-nitrobenzoyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine

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Technology Process of 1,4,5,6-tetrahydro-6-(4-nitrobenzoyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine

There total 9 articles about 1,4,5,6-tetrahydro-6-(4-nitrobenzoyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 8-[(dimethylamino)methylene]-5-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-9H-pyrido[3,2-b]azepin-9-one

: 203636-53-7
1,4,5,6-tetrahydro-6-(4-nitrobenzoyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine

Guidance literature:: With hydrazine; In ethanol; for 2h; Heating;
DOI:10.1002/jhet.5570370107

Reference yield:

: 8-[(dimethylamino)methylene]-5,6,7,8-tetrahydro-5-(4-nitrobenzoyl)-9H-pyrido[3,2-b]azepin-9-one

: 203636-53-7
1,4,5,6-tetrahydro-6-(4-nitrobenzoyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine

Guidance literature:: With hydrazine hydrate;

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 203636-53-7
1,4,5,6-tetrahydro-6-(4-nitrobenzoyl)pyrazolo[3,4-d]pyrido[3,2-b]azepine

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / triethylamine / CH₂Cl₂ / 4 h / 20 °C

2: 85 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

3: 95 percent / toluene / 5 h / Heating

4: potassium carbonate / tetrahydrofuran; methanol / 3.5 h / 20 °C

5: 49 percent / DMSO; cyanuric chloride; trietylamine / CH₂Cl₂ / 8 h / -20 °C

6: 70 percent / CH₂Cl₂ / 23 h / Heating

7: 77 percent / hydrazine / ethanol / 2 h / Heating

With 1,3,5-trichloro-2,4,6-triazine; potassium carbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 1: Acylation / 2: Oxidation / 3: Acetylation / 4: Hydrolysis / 5: Oxidation / 6: Condensation / 7: cyclocondensation;
DOI:10.1002/jhet.5570370107