(E)-1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

Base Information

• Chemical Name: (E)-1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone
• CAS No.: 179694-21-4
• Molecular Formula: C₂₈H₂₉ClN₂O₂
• Molecular Weight: 461.003
• Mol file: 179694-21-4.mol

Synonyms:(E)-1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

Chemical Property of (E)-1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone

There total 1 articles about (E)-1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-dimethylaminocinnamic acid (1552-96-1) + (+/-)-7-chloro-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (73445-60-0) → (E)-1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone (179694-21-4)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jm960143p

Reference yield: 85.0%

(E)-1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone (179694-21-4) → {4-[(E)-3-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propenyl]-phenyl}-dimethyl-amine (179694-22-5)

Guidance literature:

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jm960143p

Reference yield:

(E)-1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-3-(4-dimethylamino-phenyl)-propenone (179694-21-4) → 8-Chloro-3-[(E)-3-(4-dimethylamino-phenyl)-allyl]-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 75 percent / BBr₃ / CHCl₃; CH₂Cl₂ / 1 h / Ambient temperature

With lithium aluminium tetrahydride; sulfuric acid; boron tribromide; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1021/jm960143p

upstream raw materials:

4-dimethylaminocinnamic acid

(+/-)-7-chloro-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Downstream raw materials:

{4-[(E)-3-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propenyl]-phenyl}-dimethyl-amine