2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester

Base Information

Chemical Name:2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester
CAS No.:850404-91-0
Molecular Formula:C₂₇H₃₆O₆S
Molecular Weight:488.645
Hs Code.:

Synonyms:2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester

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Chemical Property of 2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester

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Technology Process of 2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester

There total 4 articles about 2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 850404-88-5
(3R)-5-benzyloxy-3-methoxypentanal

: 850404-89-6
(2S,3S)-2,4,6-trimethylbenzenesulfonic acid 3-(dimethylphenylsilanyl)-2-(trimethylsilanyloxy)pent-4-enyl ester

: 2,4,6-trimethylbenzenesulfonic acid (2R,6R)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester

: 850404-91-0
2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; at -78 ℃; for 12h;
DOI:10.1021/jo0610412

Reference yield:

: 850405-00-4
(2S,3S)-3-(Dimethyl-phenyl-silanyl)-pent-4-ene-1,2-diol

: 850404-91-0
2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / 4-(dimethylamino)pyridine; pyridine / CH₂Cl₂ / 72 h / 20 °C

2: 92 percent / pyridine / tetrahydrofuran / 12 h

3: 80 percent / TfOH / CH₂Cl₂ / 12 h / -78 °C

With pyridine; dmap; trifluorormethanesulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0610412

Reference yield:

: 850405-01-5
2,4,6-Trimethyl-benzenesulfonic acid (2S,3S)-3-(dimethyl-phenyl-silanyl)-2-hydroxy-pent-4-enyl ester

: 850404-91-0
2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / pyridine / tetrahydrofuran / 12 h

2: 80 percent / TfOH / CH₂Cl₂ / 12 h / -78 °C

With pyridine; trifluorormethanesulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0610412