tert-butyl N-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate

Base Information

• Chemical Name: tert-butyl N-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate
• CAS No.: 917388-79-5
• Molecular Formula: C₁₉H₂₃N₃O₄S₂
• Molecular Weight: 421.541
• Mol file: 917388-79-5.mol

Synonyms:tert-butyl N-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate

Chemical Property of tert-butyl N-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate

There total 2 articles about tert-butyl N-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate (917388-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / dichloromethane; water / 6 h / 0 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In dichloromethane; water;

DOI:10.1021/jm300931y

Reference yield:

N-(tert-butyloxycarbonyl)-S-methylisothiourea (173998-77-1) + 3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxylic acid (16188-20-8) → tert-butyl N-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate (917388-79-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 3h;

DOI:10.1021/jm300931y

Reference yield:

3,5-dichloro-4-acetamidobenzylamine (918451-59-9) + tert-butyl N-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate (917388-79-5) → C27H29Cl2N5O5S

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm300931y

upstream raw materials:

di-tert-butyl dicarbonate

N-(tert-butyloxycarbonyl)-S-methylisothiourea

3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxylic acid

Downstream raw materials:

N-((4-(2-bromoacetamido)-3,5-dichlorobenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

N-(amino(3,5-dichloro-4-(2-(dimethylamino)acetamido)-benzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

N-(amino(3-chloro-4-(2-(dimethylamino)acetamido)-5-methylbenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide