N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

Base Information

Chemical Name:N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide
CAS No.:917388-91-1
Molecular Formula:C₂₈H₃₁BrClN₅O₅S
Molecular Weight:665.008
Hs Code.:

N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

Synonyms:N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

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Chemical Property of N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

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Technology Process of N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

There total 7 articles about N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1402164-73-1,917475-50-4
tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate

: 598-21-0
2-Bromoacetyl bromide

: 917388-91-1
N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm300931y

Reference yield:

: 158296-69-6
4-amino-3-chloro-5-methylbenzonitrile

: 917388-91-1
N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / -20 - 65 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm300931y

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 917388-91-1
N-((4-(2-bromoacetamido)-3-chloro-5-methylbenzylamino)(tertbutoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / dichloromethane; water / 6 h / 0 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water;
DOI:10.1021/jm300931y