(S)-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-3-hydroxy-2-(2-hydroxy-acetylamino)-propionamide

Base Information

Chemical Name:(S)-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-3-hydroxy-2-(2-hydroxy-acetylamino)-propionamide
CAS No.:1383709-00-9
Molecular Formula:C₂₂H₂₀FN₃O₅
Molecular Weight:425.416
Hs Code.:

Synonyms:(S)-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-3-hydroxy-2-(2-hydroxy-acetylamino)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-3-hydroxy-2-(2-hydroxy-acetylamino)-propionamide

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Technology Process of (S)-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-3-hydroxy-2-(2-hydroxy-acetylamino)-propionamide

There total 2 articles about (S)-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-3-hydroxy-2-(2-hydroxy-acetylamino)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 79-14-1
glycolic Acid

: (S)-2-amino-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pridin-2-yl}-3-hydroxy-propionamide hydrochloride

: 1383709-00-9
(S)-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-3-hydroxy-2-(2-hydroxy-acetylamino)-propionamide

Guidance literature:: (S)-2-amino-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pridin-2-yl}-3-hydroxy-propionamide hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

glycolic Acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 1383708-99-3
((S)-1-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-ylcarbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester

: 1383709-00-9
(S)-N-{6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-3-hydroxy-2-(2-hydroxy-acetylamino)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 2 h / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;