[2-Amino-5-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester

Base Information

Chemical Name:[2-Amino-5-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester
CAS No.:1027250-98-1
Molecular Formula:C₁₈H₁₇ClF₃NO₃S
Molecular Weight:419.852
Hs Code.:

Synonyms:[2-Amino-5-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester

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Chemical Property of [2-Amino-5-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester

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Technology Process of [2-Amino-5-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester

There total 1 articles about [2-Amino-5-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78068-85-6
3-chloro-4-fluoro benzotrifluoride

: 1027250-98-1
[2-Amino-5-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / K₂CO₃ / dimethylformamide / 66 h / 100 °C

2: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

With chlorine; potassium carbonate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jo00043a044

Reference yield: 49.0%

: 1027250-98-1
[2-Amino-5-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester

: 138937-64-1
5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one

Guidance literature:: toluene-4-sulfonic acid; In toluene; Heating;
DOI:10.1021/jo00043a044

Reference yield:

: 1027250-98-1
[2-Amino-5-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester

: 142721-06-0
1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 49 percent / p-toluenesulfonic acid / toluene / Heating

2: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

3: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

4: 73 percent / deactivated Raney nickel (heated at reflux in acetone for 2 h) / ethanol / Ambient temperature

With deactivated Raney nickel (heated at reflux in acetone for 2 h); sodium hydride; toluene-4-sulfonic acid; In ethanol; toluene;
DOI:10.1021/jo00043a044