methyl 3-(4'-(2,6-difluorobenzamido)-6-methyl-[1,1'-biphenyl]-3-yl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydroisoxazole-5-carboxylate

Base Information

Chemical Name:methyl 3-(4'-(2,6-difluorobenzamido)-6-methyl-[1,1'-biphenyl]-3-yl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydroisoxazole-5-carboxylate
CAS No.:1373938-80-7
Molecular Formula:C₂₈H₂₄F₂N₂O₆
Molecular Weight:522.505
Hs Code.:

Synonyms:methyl 3-(4'-(2,6-difluorobenzamido)-6-methyl-[1,1'-biphenyl]-3-yl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydroisoxazole-5-carboxylate

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Chemical Property of methyl 3-(4'-(2,6-difluorobenzamido)-6-methyl-[1,1'-biphenyl]-3-yl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydroisoxazole-5-carboxylate

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Technology Process of methyl 3-(4'-(2,6-difluorobenzamido)-6-methyl-[1,1'-biphenyl]-3-yl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydroisoxazole-5-carboxylate

There total 4 articles about methyl 3-(4'-(2,6-difluorobenzamido)-6-methyl-[1,1'-biphenyl]-3-yl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydroisoxazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373940-67-0
2,6-difluoro-N-(5'-((hydroxyimino)methyl)-2'-methyl-[1,1'-biphenyl]-4-yl)benzamide

: 617-52-7
Dimethyl itakonate

: 1373938-80-7
methyl 3-(4'-(2,6-difluorobenzamido)-6-methyl-[1,1'-biphenyl]-3-yl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydroisoxazole-5-carboxylate

Guidance literature:: 2,6-difluoro-N-(5'-((hydroxyimino)methyl)-2'-methyl-[1,1'-biphenyl]-4-yl)benzamide; With pyridine; N-chloro-succinimide; In tetrahydrofuran; at 70 ℃; for 1h;

Dimethyl itakonate; With triethylamine; In tetrahydrofuran; at 20 - 70 ℃; for 2h;

Reference yield:

: 903522-11-2
2,6-difluoro-N-(4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide

: 1373938-80-7
methyl 3-(4'-(2,6-difluorobenzamido)-6-methyl-[1,1'-biphenyl]-3-yl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydroisoxazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium carbonate / water; methanol / 1 h / 0 - 20 °C

3.1: N-chloro-succinimide; pyridine / tetrahydrofuran / 1 h / 70 °C

3.2: 2 h / 20 - 70 °C

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 36276-24-1
3-bromo-4-methyl-benzaldehyde

: 1373938-80-7
methyl 3-(4'-(2,6-difluorobenzamido)-6-methyl-[1,1'-biphenyl]-3-yl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydroisoxazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium carbonate / water; methanol / 1 h / 0 - 20 °C

3.1: N-chloro-succinimide; pyridine / tetrahydrofuran / 1 h / 70 °C

3.2: 2 h / 20 - 70 °C

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; water;