5-Pyrimidinol,4,6-dichloro-(9CI)

Base Information

• Chemical Name: 5-Pyrimidinol,4,6-dichloro-(9CI)
• CAS No.: 425394-89-4
• Molecular Formula: C4H2 Cl2 N2 O
• Molecular Weight: 164.979
• Hs Code.: 2933599090
• Mol file: 425394-89-4.mol

Synonyms:4,6-Dichloro-5-hydroxypyrimidine

Chemical Property of 5-Pyrimidinol,4,6-dichloro-(9CI)

Chemical Property:

• Boiling Point: 242℃
• PKA: 3.66±0.20(Predicted)
• Flash Point: 100℃
• PSA: 46.01000
• Density: 1.679
• LogP: 1.48900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4,6-Dichloropyrimidin-5-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Pyrimidinol,4,6-dichloro-(9CI)

There total 1 articles about 5-Pyrimidinol,4,6-dichloro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.11%

4,6-dichloro-5-methoxypyrimidine (5018-38-2) → 4,6-dichloropyrimidin-5-ol (425394-89-4)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 50 ℃; for 6h;

Reference yield: 94.0%

4,6-dichloropyrimidin-5-ol (425394-89-4) + benzyl bromide (100-39-0) → 5-(benzyloxy)-4,6-dichloropyrimidine (1206181-50-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

Reference yield: 38.0%

4,6-dichloropyrimidin-5-ol (425394-89-4) + tert-butyl ((cis)-4-(hydroxymethyl)cyclohexyl)carbamate (223131-01-9) → tert-butyl (cis-4-(((4,6-dichloropyrimidin-5-yl)oxy)methyl)cyclohexyl)carbamate

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

upstream raw materials:

4,6-dichloro-5-methoxypyrimidine

Downstream raw materials:

5-(benzyloxy)-4,6-dichloropyrimidine

Refernces

• 1、 -. "LPXC INHIBITOR AND METHODS OF MAKING". Paragraph 00260; 00261. . Retrieved 2021/10/02.
• 2、 -. "PYRAZOLYL COMPOUNDS AND METHODS OF USE THEREOF". Paragraph 0633-0636. . Retrieved 2020/05/14.