2-Amino-1-((S)-1-p-tolyl-ethyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile

Base Information

• Chemical Name: 2-Amino-1-((S)-1-p-tolyl-ethyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile
• CAS No.: 177499-68-2
• Molecular Formula: C₁₈H₂₁N₃
• Molecular Weight: 279.385
• Mol file: 177499-68-2.mol

Synonyms:2-Amino-1-((S)-1-p-tolyl-ethyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile

Chemical Property of 2-Amino-1-((S)-1-p-tolyl-ethyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-Amino-1-((S)-1-p-tolyl-ethyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile

There total 1 articles about 2-Amino-1-((S)-1-p-tolyl-ethyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-(4-methylphenyl)ethylamine (27298-98-2) + cyclohexanone-2-ol (533-60-8) + malononitrile (109-77-3) → 2-Amino-1-((S)-1-p-tolyl-ethyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile (177499-68-2)

Guidance literature:

With piperidine; toluene-4-sulfonic acid; Yield given. Multistep reaction; 1.) cyclohexane, reflux, 2.) cyclohexane, reflux;

DOI:10.1021/jm960011w

Reference yield: 52.0%

benzonitrile (100-47-0) + 2-Amino-1-((S)-1-p-tolyl-ethyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile (177499-68-2) → 2-Phenyl-9-((S)-1-p-tolyl-ethyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-ylamine (177499-72-8)

Guidance literature:

With sodium methylate; In isopropyl alcohol; Heating;

DOI:10.1021/jm960011w

Reference yield:

2-Amino-1-((S)-1-p-tolyl-ethyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile (177499-68-2) → 2-Phenyl-9-((S)-1-p-tolyl-ethyl)-9H-pyrimido[4,5-b]indol-4-ylamine

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / sodium methylate / propan-2-ol / Heating

2: 72 percent / 1-methylnaphthalene / 10percent Pd/C / 4 h / Heating

With sodium methylate; 1-Methylnaphthalene; palladium on activated charcoal; In isopropyl alcohol;

DOI:10.1021/jm960011w

upstream raw materials:

(S)-1-(4-methylphenyl)ethylamine

cyclohexanone-2-ol

malononitrile

Downstream raw materials:

2-Phenyl-9-((S)-1-p-tolyl-ethyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-ylamine