5'-BROMO-2'-FLUOROBIPHENYL-2-CARBONITRILE

Base Information

• Chemical Name: 5'-BROMO-2'-FLUOROBIPHENYL-2-CARBONITRILE
• CAS No.: 425378-71-8
• Molecular Formula: C13H7 Br F N
• Molecular Weight: 276.108
• Mol file: 425378-71-8.mol

Synonyms:5'-Bromo-2'-fluorobiphenyl-2-carbonitrile

Chemical Property of 5'-BROMO-2'-FLUOROBIPHENYL-2-CARBONITRILE

Chemical Property:

• Boiling Point: 370.5±32.0 °C(Predicted)
• PSA: 23.79000
• Density: 1.55±0.1 g/cm3(Predicted)
• LogP: 4.12688

Purity/Quality:

97% ^*data from raw suppliers

5'-BROMO-2'-FLUOROBIPHENYL-2-CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-BROMO-2'-FLUOROBIPHENYL-2-CARBONITRILE

There total 6 articles about 5'-BROMO-2'-FLUOROBIPHENYL-2-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

5'-amino-2'-fluorobiphenyl-2-carbonitrile (425378-70-7) → 5'-bromo-2'-fluorobiphenyl-2-carbonitrile (425378-71-8)

Guidance literature:

With hydrogen bromide; copper(I) bromide; sodium nitrite; In 1,4-dioxane; at 5 - 50 ℃; for 0.5h;

DOI:10.1021/jm051065l

Reference yield: 64.0%

→ 5'-bromo-2'-fluorobiphenyl-2-carbonitrile (425378-71-8)

Guidance literature:

Reference yield:

2'-fluoro-5'-nitrobiphenyl-2-carbonitrile (425378-69-4) → 5'-bromo-2'-fluorobiphenyl-2-carbonitrile (425378-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / SnCl₂*2H₂O / ethanol; tetrahydrofuran / 12 h / 20 °C

2: 64 percent / aq. HBr; NaNO₂; CuBr / dioxane / 0.5 h / 5 - 50 °C

With hydrogen bromide; tin(ll) chloride; copper(I) bromide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; ethanol; 2: Sandmeyer reaction;

DOI:10.1021/jm051065l

upstream raw materials:

5'-amino-2'-fluorobiphenyl-2-carbonitrile

2'-fluoro-5'-nitrobiphenyl-2-carbonitrile

2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

o-cyanobromobenzene

Downstream raw materials:

2'-fluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile

5'-(8-chloro-imidazo[1,2-a]pyrazin-3-yl)-2'-fluoro-biphenyl-2-carbonitrile

2'-fluoro-5'-(8-methoxyimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile

2'-fluoro-5'-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile

Refernces

• 1、 Goodacre, Simon C.,Hallett, David J.,Carling, Robert W.,Castro, Jose L.,Reynolds, David S.,Pike, Andrew,Wafford, Keith A.,Newman, Robert,Atack, John R.,Street, Leslie J.. "Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxiety". . p. 1582 - 1585. Retrieved 2007/10/03.