2-[N¹-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine

Base Information

• Chemical Name: 2-[N¹-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine
• CAS No.: 917462-07-8
• Molecular Formula: C₁₆H₁₅N₅O₄S₂
• Molecular Weight: 405.458

Synonyms:2-[N¹-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine

Chemical Property of 2-[N¹-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine

Chemical Property:

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Technology Process of 2-[N¹-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine

There total 4 articles about 2-[N¹-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-amino-4-[2-methylthio-[1,3,4]-oxadiazol-5-yl]pyridine (917462-05-6) + p-acetylaminobenzenesulfonyl chloride (121-60-8) → 2-[N1-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine (917462-07-8)

Guidance literature:

With pyridine; In acetone; at 20 ℃;

Reference yield:

5-(2-aminopyridin-4-yl)-3H-[1,3,4]oxadiazol-2-thione (917462-04-5) → 2-[N1-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine (917462-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. NaOH / methanol / 0.25 h / 20 °C

1.2: 85 percent / methanol / 5 h / 20 °C

2.1: 85 percent / pyridine / acetone / 20 °C

With pyridine; sodium hydroxide; In methanol; acetone;

Reference yield:

methyl 2-aminoisonicotinate (6937-03-7) → 2-[N1-(4-acetylsulfanilamido)]-4-[5-(methylthio)-[1,3,4]-oxadiazol-2-yl]pyridine (917462-07-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 90 percent / hydrazine hydrate / methanol / 3 h / Heating

2.1: 54 percent / KOH / methanol / 10 h / Heating

3.1: aq. NaOH / methanol / 0.25 h / 20 °C

3.2: 85 percent / methanol / 5 h / 20 °C

4.1: 85 percent / pyridine / acetone / 20 °C

With pyridine; potassium hydroxide; sodium hydroxide; hydrazine hydrate; In methanol; acetone;

upstream raw materials:

2-amino-4-[2-methylthio-[1,3,4]-oxadiazol-5-yl]pyridine

p-acetylaminobenzenesulfonyl chloride

5-(2-aminopyridin-4-yl)-3H-[1,3,4]oxadiazol-2-thione

methyl 2-aminoisonicotinate

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