N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

Base Information

Chemical Name:N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine
CAS No.:1191279-81-8
Molecular Formula:C₂₂H₁₈N₄O
Molecular Weight:354.411
Hs Code.:

N<sub>2</sub>-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

Synonyms:N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

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Technology Process of N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

There total 3 articles about N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine: 1191279-74-9
N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine

N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine: 1191279-81-8
N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

Guidance literature:: With ammonium hydroxide; sodium dithionite; In tetrahydrofuran; water; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2009.07.080

Reference yield:

: 1191279-71-6
N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-iodo)phenoxy-3-nitropyridin-2-amine

N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine: 1191279-81-8
N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; copper(l) iodide / C₄₁H₃₅ClP₂Pd / N,N-dimethyl-formamide / 7 h / 20 °C / Inert atmosphere

2: sodium hydroxide / toluene / 24 h / Inert atmosphere; Reflux

3: sodium dithionite; ammonia / water; tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; sodium dithionite; ammonia; triethylamine; sodium hydroxide; C₄₁H₃₅ClP₂Pd; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1191279-73-8
N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine

N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine: 1191279-81-8
N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / toluene / 24 h / Inert atmosphere; Reflux

2: sodium dithionite; ammonia / tetrahydrofuran; water / 2 h / 20 °C

With sodium dithionite; ammonia; sodium hydroxide; In tetrahydrofuran; water; toluene;