4-(3-chloropropoxy)benzamide

Base Information

• Chemical Name: 4-(3-chloropropoxy)benzamide
• CAS No.: 111627-48-6
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.664
• Mol file: 111627-48-6.mol

Synonyms:4-(3-chloropropoxy)benzamide

Chemical Property of 4-(3-chloropropoxy)benzamide

Chemical Property:

• Melting Point: 142-143 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 383.1±17.0 °C(Predicted)
• PKA: 16.30±0.50(Predicted)
• Density: 1.210±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-chloropropoxy)benzamide

There total 1 articles about 4-(3-chloropropoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

p-hydroxybenzamide (619-57-8) + 1.3-chlorobromopropane (109-70-6) → 4-(3-chloropropoxy)benzamide (111627-48-6)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Heating;

DOI:10.1021/jm00121a022

Reference yield: 96.0%

methyl 2-chloroacetoacetate (4755-81-1,935731-92-3) + 4-(3-chloropropoxy)benzamide (111627-48-6) → methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-oxazole-5-carboxylate (911134-52-6)

Guidance literature:

In ethanol; at 110 ℃; for 24h;

Reference yield: 88.0%

4-(3-chloropropoxy)benzamide (111627-48-6) → 4-(3-chloropropoxy)benzenecarbothioamide (911134-67-3)

Guidance literature:

With Lawessons reagent; In chloroform; at 22 ℃; for 12h;

DOI:10.1002/cmdc.201100248

upstream raw materials:

p-hydroxybenzamide

1.3-chlorobromopropane

Downstream raw materials:

4-[3-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]propoxy]benzamide

4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzamide

ethyl 2-[4-(3-chloropropoxy)phenyl]-1,3-oxazole-4-carboxylate

4-(3-chloropropoxy)benzenecarbothioamide

Refernces

• 1、 -. "AZABICYCLO[3.1.0]HEX-2-YL COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". Page/Page column 4. . Retrieved 2012/11/13.
• 2、 -. "Azabicyclo[3.2.0] hept-3-yl compounds, a process for their preparation and pharmaceutical compositions containing them". Page/Page column 3. . Retrieved 2011/06/24.