FP-Tztp

Base Information

• Chemical Name: FP-Tztp
• CAS No.: 424829-90-3
• Molecular Formula: C₁₁H₁₆FN₃S₂
• Molecular Weight: 273.399
• UNII: C2LNI0YP8Z
• DSSTox Substance ID: DTXSID50435762
• Nikkaji Number: J645.733I
• Pharos Ligand ID: D1ZGNMCW2958
• ChEMBL ID: CHEMBL2112939
• Mol file: 424829-90-3.mol

Synonyms:3-(3-(3-fluoropropyl)thio)-1,2,5-thiadiazol-4-yl-1,2,5,6-tetrahydro-1-methylpyridine;FP-TZTP

Chemical Property of FP-Tztp

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.588
• Boiling Point: 385.086°C at 760 mmHg
• Flash Point: 186.693°C
• Density: 1.282g/cm³
• Storage Temp.: Amber Vial, -86°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 273.07696803
• Heavy Atom Count: 17
• Complexity: 275

Purity/Quality:

97% ^*data from raw suppliers

FP-TZTP,>85% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC=C(C1)C2=NSN=C2SCCCF
• Uses: It is an M2 selective muscarinic agonist that may allow noninvasive studies of Alzheimer disease with PET. It is an M2 selective muscarinic agonist that may allow noninvasive studies of Alzheimer's disease with PET. It is an M2 selective muscarinic agonist that may allow noninvasive studies of Alzheimer''s disease with PET.

Technology Process of FP-Tztp

There total 4 articles about FP-Tztp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

3-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-ylthio)propyl-4-methylbenzenesulfonate (1190100-98-1) → 3-(3-((3-fluoropropyl)thio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine (424829-90-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 3h; Reflux;

DOI:10.1139/V10-149

Reference yield:

3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (131986-28-2) → 3-(3-((3-fluoropropyl)thio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine (424829-90-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Li₂S / dimethylformamide

3: NaBH₄

With sodium tetrahydroborate; lithium sulfide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00001a002

Reference yield:

4-Pyridin-3-yl-[1,2,5]thiadiazole-3-thiol (908375-51-9) → 3-(3-((3-fluoropropyl)thio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine (424829-90-3)

Guidance literature:

Multi-step reaction with 2 steps

2: NaBH₄

With sodium tetrahydroborate;

DOI:10.1021/jm00001a002

upstream raw materials:

methyl iodide

3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine

4-Pyridin-3-yl-[1,2,5]thiadiazole-3-thiol

3-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-ylthio)propyl-4-methylbenzenesulfonate

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