2-((1S,2S)-2-Benzyloxy-1-methyl-3-(S)-oxiranyl-propyl)-isoindole-1,3-dione

Base Information

Chemical Name:2-((1S,2S)-2-Benzyloxy-1-methyl-3-(S)-oxiranyl-propyl)-isoindole-1,3-dione
CAS No.:209340-84-1
Molecular Formula:C₂₁H₂₁NO₄
Molecular Weight:351.402
Hs Code.:

Synonyms:2-((1S,2S)-2-Benzyloxy-1-methyl-3-(S)-oxiranyl-propyl)-isoindole-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((1S,2S)-2-Benzyloxy-1-methyl-3-(S)-oxiranyl-propyl)-isoindole-1,3-dione

Chemical Property:

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Technology Process of 2-((1S,2S)-2-Benzyloxy-1-methyl-3-(S)-oxiranyl-propyl)-isoindole-1,3-dione

There total 9 articles about 2-((1S,2S)-2-Benzyloxy-1-methyl-3-(S)-oxiranyl-propyl)-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Toluene-4-sulfonic acid (2S,4S,5S)-4-benzyloxy-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-hydroxy-hexyl ester

: 209340-84-1
2-((1S,2S)-2-Benzyloxy-1-methyl-3-(S)-oxiranyl-propyl)-isoindole-1,3-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Yield given;
DOI:10.1016/S0040-4039(98)00588-7

Reference yield:

: 100-39-0
benzyl bromide

: 209340-84-1
2-((1S,2S)-2-Benzyloxy-1-methyl-3-(S)-oxiranyl-propyl)-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 3 h / Ambient temperature

2: pTSA / methanol / 2 h / Ambient temperature

3: pyridine / CH₂Cl₂ / 12 h / 0 °C

4: NaH / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)00588-7

Reference yield:

: 209341-04-8
2-((1S,2S,4S)-2,4,5-Trihydroxy-1-methyl-pentyl)-isoindole-1,3-dione

: 209340-84-1
2-((1S,2S)-2-Benzyloxy-1-methyl-3-(S)-oxiranyl-propyl)-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / CSA / CH₂Cl₂ / 1 h / Ambient temperature

2: NaH / tetrahydrofuran / 3 h / Ambient temperature

3: pTSA / methanol / 2 h / Ambient temperature

4: pyridine / CH₂Cl₂ / 12 h / 0 °C

5: NaH / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; camphor-10-sulfonic acid; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)00588-7