N-(3-Fluorobenzyl)-4-Methoxyaniline, 97%

Base Information

• Chemical Name: N-(3-Fluorobenzyl)-4-Methoxyaniline, 97%
• CAS No.: 415968-77-3
• Molecular Formula: C₁₄H₁₄FNO
• Molecular Weight: 231.27
• Mol file: 415968-77-3.mol

Synonyms:N-(3-fluorobenzyl)-4-methoxyaniline

Chemical Property of N-(3-Fluorobenzyl)-4-Methoxyaniline, 97%

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-[(3-Fluorophenyl)methyl]-4-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-Fluorobenzyl)-4-Methoxyaniline, 97%

There total 2 articles about N-(3-Fluorobenzyl)-4-Methoxyaniline, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-methoxy-aniline (104-94-9) + 3-Fluorobenzaldehyde (456-48-4) → N-(3-fluorobenzyl)-4-methoxyaniline (415968-77-3)

Guidance literature:

With triiron dodecarbonyl; hydrogen; In toluene; at 65 ℃; for 24h; under 37503.8 Torr; Autoclave;

DOI:10.1002/asia.201100462

Reference yield: 43.0%

3-fluoro-benzenemethanol (456-47-3) + 4-methoxy-aniline (104-94-9) → N-(3-fluorobenzyl)-4-methoxyaniline (415968-77-3)

Guidance literature:

With tris(pentafluorophenyl)borate; In toluene; at 120 ℃; for 36h; chemoselective reaction; Molecular sieve; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.9b02816

Reference yield: 47.0%

N-(3-fluorobenzyl)-4-methoxyaniline (415968-77-3) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(3-fluorobenzyl)-N-(4-methoxyphenyl)acetamide

Guidance literature:

In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1021/ol503595m

upstream raw materials:

4-methoxy-aniline

3-Fluorobenzaldehyde

3-fluoro-benzenemethanol

Refernces

• 1、 Kolesnikov, Pavel N.,Yagafarov, Niyaz Z.,Usanov, Dmitry L.,Maleev, Victor I.,Chusov, Denis. "Ruthenium-catalyzed reductive amination without an external hydrogen source". supporting information. p. 173 - 175. Retrieved 2015/01/30.