tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Base Information

Chemical Name:tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate
CAS No.:1610458-35-9
Molecular Formula:C₂₆H₂₇F₃N₆O₃
Molecular Weight:528.534
Hs Code.:

tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Synonyms:tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

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Chemical Property of tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

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Technology Process of tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

There total 14 articles about tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610458-34-8
tert-butyl ((7R,8S)-3-(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

: 74-88-4
methyl iodide

: 1610458-35-9
tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

: 1384126-47-9
1,2,4-trifluoro-5-(3-methoxy-6-nitrocyclohex-3-enyl)benzene

: 1610458-35-9
tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Guidance literature:: Multi-step reaction with 12 steps

1.1: N-Bromosuccinimide; sodium acetate / water; tetrahydrofuran / 0.5 h / 0 °C

2.1: 2-methyl-propan-1-ol / 5 h / -10 - 0 °C / Reflux

3.1: zinc; ammonium chloride; acetic acid / water; tetrahydrofuran / 2 h / 50 °C

4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

5.1: hydrogenchloride / water / 24 h / 100 °C / pH 12

6.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C

7.1: hydrogenchloride / water / 100 °C

8.1: potassium carbonate / methanol / 20 °C

9.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

9.2: 3 h / 0 - 20 °C

10.1: methanol / 20 °C / Reflux

11.1: sodium hydroxide / Reflux

12.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With hydrogenchloride; N-Bromosuccinimide; dihydrogen peroxide; sodium acetate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; In tetrahydrofuran; methanol; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1384175-49-8
8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carbonitrile

: 1610458-35-9
tert-butyl ((7R,8S)-3-(1,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2.1: hydrogenchloride / water / 24 h / 100 °C / pH 12

3.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C

4.1: hydrogenchloride / water / 100 °C

5.1: potassium carbonate / methanol / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

6.2: 3 h / 0 - 20 °C

7.1: methanol / 20 °C / Reflux

8.1: sodium hydroxide / Reflux

9.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With hydrogenchloride; dihydrogen peroxide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;