(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol

Base Information

Chemical Name:(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol
CAS No.:1401728-65-1
Molecular Formula:C₂₀H₂₃N₃O
Molecular Weight:321.422
Hs Code.:

Synonyms:(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol

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Chemical Property of (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol

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Technology Process of (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol

There total 5 articles about (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1401728-64-0
(E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]acrylic acid methyl ester

: 1401728-65-1
(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01703

Reference yield:

: 57775-08-3
3-(4-Bromo-phenyl)-propionitrile

: 1401728-65-1
(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium 2-methylbutan-2-olate / tetrahydrofuran; toluene / 20 °C

1.2: 0.33 h / 20 °C

2.1: acetic acid; hydrazine hydrate / ethanol / 0.25 h / 140 °C / Microwave irradiation

2.2: 160 °C

3.1: trifluoroacetic acid / 1,4-dioxane / 20 °C

4.1: bis(tri-t-butylphosphine)palladium ⁽⁰⁾; N-Methyldicyclohexylamine / 1,4-dioxane / 0.08 h / 130 °C / Microwave irradiation

5.1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 °C

With bis(tri-t-butylphosphine)palladium ⁽⁰⁾; N-Methyldicyclohexylamine; diisobutylaluminium hydride; potassium 2-methylbutan-2-olate; hydrazine hydrate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: 1401728-61-7
2-(4-bromobenzyl)-3-oxopentanenitrile

: 1401728-65-1
(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; hydrazine hydrate / ethanol / 0.25 h / 140 °C / Microwave irradiation

1.2: 160 °C

2.1: trifluoroacetic acid / 1,4-dioxane / 20 °C

3.1: bis(tri-t-butylphosphine)palladium ⁽⁰⁾; N-Methyldicyclohexylamine / 1,4-dioxane / 0.08 h / 130 °C / Microwave irradiation

4.1: diisobutylaluminium hydride / dichloromethane / 3 h / -78 °C

With bis(tri-t-butylphosphine)palladium ⁽⁰⁾; N-Methyldicyclohexylamine; diisobutylaluminium hydride; hydrazine hydrate; acetic acid; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane;