((3-azidopropoxy)methyl)benzene

Base Information

• Chemical Name: ((3-azidopropoxy)methyl)benzene
• CAS No.: 57294-87-8
• Molecular Formula: C₁₀H₁₃N₃O
• Molecular Weight: 191.233
• Mol file: 57294-87-8.mol

Synonyms:((3-azidopropoxy)methyl)benzene

Chemical Property of ((3-azidopropoxy)methyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((3-azidopropoxy)methyl)benzene

There total 2 articles about ((3-azidopropoxy)methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.1%

benzyl bromide (100-39-0) + trimethyleneglycol (504-63-2) → ((3-azidopropoxy)methyl)benzene (57294-87-8)

Guidance literature:

trimethyleneglycol; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Further stages;

DOI:10.1016/j.bioorg.2018.08.030

Reference yield: 37.0%

3-benzyloxypropan-1-ol (4799-68-2) → ((3-azidopropoxy)methyl)benzene (57294-87-8)

Guidance literature:

3-benzyloxypropan-1-ol; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 20 ℃;

With sodium azide; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

DOI:10.1039/c8ob02298d

Reference yield: 95.0%

((3-azidopropoxy)methyl)benzene (57294-87-8) + N3-(4-fluorobenzoyl)-N1-(prop-2-yn-1-yl)quinazoline-2,4-dione → N1-{[1-(3-benzyloxypropyl)-1H-1,2,3-triazol-4-yl]methyl}-N3-(4-fluorobenzoyl)quinazoline-2,4-dione

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In ethanol; water; at 40 - 45 ℃; for 0.5h; Temperature; Microwave irradiation;

DOI:10.1002/ardp.201700166

upstream raw materials:

benzyl bromide

trimethyleneglycol

3-benzyloxypropan-1-ol

Downstream raw materials:

3-benzyloxypropylamine