(Z)-2-(5-(2-chlorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

Base Information

Chemical Name:(Z)-2-(5-(2-chlorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide
CAS No.:1390675-42-9
Molecular Formula:C₂₂H₂₂ClN₃O₄S₂
Molecular Weight:492.019
Hs Code.:

Synonyms:(Z)-2-(5-(2-chlorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-(5-(2-chlorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

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Technology Process of (Z)-2-(5-(2-chlorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

There total 2 articles about (Z)-2-(5-(2-chlorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390675-59-8
C₁₅H₁₅ClN₂O₃S

: 70-55-3
toluene-4-sulfonamide

: 1390675-42-9
(Z)-2-(5-(2-chlorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2012.05.079

Reference yield:

: 81154-08-7,81154-00-9
(5Z)-5-(2-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one

: 1390675-42-9
(Z)-2-(5-(2-chlorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-methyl-N-tosylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 2.17 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 7 h / 70 - 80 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2012.05.079