2-(6-bromoquinolin-3-yl)-N-(4-fluorophenyl)-6-(5-(4-fluorophenyl)-1H-imidazol-2-yl)imidazo[1,2-a]pyridin-3-amine

Base Information

Chemical Name:2-(6-bromoquinolin-3-yl)-N-(4-fluorophenyl)-6-(5-(4-fluorophenyl)-1H-imidazol-2-yl)imidazo[1,2-a]pyridin-3-amine
CAS No.:1297399-19-9
Molecular Formula:C₃₁H₁₉BrF₂N₆
Molecular Weight:593.433
Hs Code.:

Synonyms:2-(6-bromoquinolin-3-yl)-N-(4-fluorophenyl)-6-(5-(4-fluorophenyl)-1H-imidazol-2-yl)imidazo[1,2-a]pyridin-3-amine

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Chemical Property of 2-(6-bromoquinolin-3-yl)-N-(4-fluorophenyl)-6-(5-(4-fluorophenyl)-1H-imidazol-2-yl)imidazo[1,2-a]pyridin-3-amine

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Technology Process of 2-(6-bromoquinolin-3-yl)-N-(4-fluorophenyl)-6-(5-(4-fluorophenyl)-1H-imidazol-2-yl)imidazo[1,2-a]pyridin-3-amine

There total 5 articles about 2-(6-bromoquinolin-3-yl)-N-(4-fluorophenyl)-6-(5-(4-fluorophenyl)-1H-imidazol-2-yl)imidazo[1,2-a]pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₁₉BrF₂N₄O₃

: 1297399-19-9
2-(6-bromoquinolin-3-yl)-N-(4-fluorophenyl)-6-(5-(4-fluorophenyl)-1H-imidazol-2-yl)imidazo[1,2-a]pyridin-3-amine

Guidance literature:: With ammonium acetate; acetic acid; for 5h; Reflux;
DOI:10.1016/j.ejmech.2011.02.051

Reference yield:

: 3167-49-5
6-aminonicotinic acid

: 1297399-19-9
2-(6-bromoquinolin-3-yl)-N-(4-fluorophenyl)-6-(5-(4-fluorophenyl)-1H-imidazol-2-yl)imidazo[1,2-a]pyridin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: scandium tris(trifluoromethanesulfonate) / methanol; dichloromethane / 1 h / 20 °C

1.2: 12 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 4 h / 0 °C

3.1: ammonium acetate; acetic acid / 5 h / Reflux

With ammonium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.051

Reference yield:

: 1196155-68-6
6-bromoquinoline-3-carbaldehyde

: 1297399-19-9
2-(6-bromoquinolin-3-yl)-N-(4-fluorophenyl)-6-(5-(4-fluorophenyl)-1H-imidazol-2-yl)imidazo[1,2-a]pyridin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: scandium tris(trifluoromethanesulfonate) / methanol; dichloromethane / 1 h / 20 °C

1.2: 12 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 4 h / 0 °C

3.1: ammonium acetate; acetic acid / 5 h / Reflux

With ammonium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.051