(R)-(3-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone

Base Information

Chemical Name:(R)-(3-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone
CAS No.:1446099-50-8
Molecular Formula:C₂₁H₂₄FNO₂
Molecular Weight:341.425
Hs Code.:

Synonyms:(R)-(3-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(3-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone

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Technology Process of (R)-(3-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone

There total 5 articles about (R)-(3-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.9%

: 1446099-60-0
(4-(3-chloropropoxy)phenyl)(3-fluorophenyl)methanone

: 765-38-8,41720-98-3,59335-84-1,79171-53-2
(R)-(-)-2-methylpyrrolidine

: 1446099-50-8
(R)-(3-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 24h; Inert atmosphere; Schlenk technique; Reflux;
DOI:10.1039/c3ra46392c

Reference yield:

: 190728-34-8
(3-fluorophenyl)(4-hydroxyphenyl)methanone

: 1446099-50-8
(R)-(3-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Schlenk technique; Reflux

2: potassium carbonate; potassium iodide / acetonitrile / 24 h / Inert atmosphere; Schlenk technique; Reflux

With potassium carbonate; potassium iodide; In acetonitrile;
DOI:10.1039/c3ra46392c

Reference yield:

: 100-66-3
methoxybenzene

: 1446099-50-8
(R)-(3-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 4 h / 20 - 40 °C / Inert atmosphere; Schlenk technique

2: hydrogen bromide; acetic acid / 24 h / Inert atmosphere; Schlenk technique; Reflux

3: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Schlenk technique; Reflux

4: potassium carbonate; potassium iodide / acetonitrile / 24 h / Inert atmosphere; Schlenk technique; Reflux

With aluminum (III) chloride; hydrogen bromide; potassium carbonate; acetic acid; potassium iodide; In dichloromethane; acetonitrile; 1: |Friedel-Crafts Acylation;
DOI:10.1039/c3ra46392c