N-dodecanyl-5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine

Base Information

Chemical Name:N-dodecanyl-5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine
CAS No.:549503-29-9
Molecular Formula:C₂₈H₄₇N₃OSi
Molecular Weight:469.786
Hs Code.:

Synonyms:N-dodecanyl-5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-dodecanyl-5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine

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Technology Process of N-dodecanyl-5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine

There total 6 articles about N-dodecanyl-5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pyrazin-2-yl}-dodecylidene-amine

: 549503-29-9
N-dodecanyl-5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine

Guidance literature:: With phenylsilane; In tetrahydrofuran; at 20 ℃;
DOI:10.1055/s-2003-37652

Reference yield:

: 106-41-2
4-bromo-phenol

: 549503-29-9
N-dodecanyl-5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: imidazole / CH₂Cl₂ / 1 h / 20 °C

2.1: BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: 51.4 mmol / triisopropylborate / hexane; tetrahydrofuran / 20 °C

3.1: 72 percent / aq. Na₂CO₃ / [1,4-bis(diphenylphosphino)butane]palladium(II) chloride / toluene / 24 h / Heating

4.1: dibutyltin dichloride / tetrahydrofuran / 0.08 h

5.1: phenylsilane / tetrahydrofuran / 20 °C

With 1H-imidazole; n-butyllithium; phenylsilane; dibutyltin chloride; sodium carbonate; PdCl₂(PPh₂(CH₂)4PPh₂); In tetrahydrofuran; hexane; dichloromethane; toluene; 3.1: Suzuki reaction;
DOI:10.1055/s-2003-37652

Reference yield:

: 67963-68-2
t-butyldimethylsilyl-4-bromophenol

: 549503-29-9
N-dodecanyl-5-(p-tert-butyldimethylsilyloxyphenyl)-2-amino-1,4-pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

1.2: 51.4 mmol / triisopropylborate / hexane; tetrahydrofuran / 20 °C

2.1: 72 percent / aq. Na₂CO₃ / [1,4-bis(diphenylphosphino)butane]palladium(II) chloride / toluene / 24 h / Heating

3.1: dibutyltin dichloride / tetrahydrofuran / 0.08 h

4.1: phenylsilane / tetrahydrofuran / 20 °C

With n-butyllithium; phenylsilane; dibutyltin chloride; sodium carbonate; PdCl₂(PPh₂(CH₂)4PPh₂); In tetrahydrofuran; hexane; toluene; 2.1: Suzuki reaction;
DOI:10.1055/s-2003-37652