2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine

Base Information

Chemical Name:2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine
CAS No.:1354910-40-9
Molecular Formula:C₂₀H₁₇F₃N₂O₂
Molecular Weight:374.362
Hs Code.:

Synonyms:2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine

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Chemical Property of 2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine

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Technology Process of 2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine

There total 10 articles about 2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354910-19-2
2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester

: 1354910-40-9
2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine

Guidance literature:: 2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester; With trifluoroacetic acid; In dichloromethane; for 16h; Reflux;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 586-75-4
4-chlorobenzoyl chloride

: 1354910-40-9
2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 64 h / 20 °C

3.1: N,N-dimethyl-formamide / 16 h

4.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C

4.2: 0.08 h

5.1: N-ethyl-N,N-diisopropylamine; carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 2.17 h / 0 °C / Reflux

5.2: 48 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

7.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane / 16 h / 80 °C

8.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 16 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 16 h / Reflux

With sodium tetrahydroborate; hexachloroethane; carbonochloridic acid 1-chloro-ethyl ester; tetrabutylammomium bromide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 6320-39-4
3-aminopyridin-4-ol

: 1354910-40-9
2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 64 h / 20 °C

3.1: N,N-dimethyl-formamide / 16 h

4.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C

4.2: 0.08 h

5.1: N-ethyl-N,N-diisopropylamine; carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 2.17 h / 0 °C / Reflux

5.2: 48 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

7.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane / 16 h / 80 °C

8.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 16 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 16 h / Reflux

With sodium tetrahydroborate; hexachloroethane; carbonochloridic acid 1-chloro-ethyl ester; tetrabutylammomium bromide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;