2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester

Base Information

Chemical Name:2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester
CAS No.:1354910-19-2
Molecular Formula:C₂₅H₂₅F₃N₂O₄
Molecular Weight:474.48
Hs Code.:

Synonyms:2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester

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Chemical Property of 2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester

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Technology Process of 2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester

There total 9 articles about 2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1354910-18-1
tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1354910-19-2
2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; at 20 ℃; for 16h;

Reference yield:

: 586-75-4
4-chlorobenzoyl chloride

: 1354910-19-2
2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 64 h / 20 °C

3.1: N,N-dimethyl-formamide / 16 h

4.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C

4.2: 0.08 h

5.1: N-ethyl-N,N-diisopropylamine; carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 2.17 h / 0 °C / Reflux

5.2: 48 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

7.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane / 16 h / 80 °C

8.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 16 h / 20 °C

With sodium tetrahydroborate; hexachloroethane; carbonochloridic acid 1-chloro-ethyl ester; tetrabutylammomium bromide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 6320-39-4
3-aminopyridin-4-ol

: 1354910-19-2
2-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 64 h / 20 °C

3.1: N,N-dimethyl-formamide / 16 h

4.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C

4.2: 0.08 h

5.1: N-ethyl-N,N-diisopropylamine; carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 2.17 h / 0 °C / Reflux

5.2: 48 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

7.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane / 16 h / 80 °C

8.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 16 h / 20 °C

With sodium tetrahydroborate; hexachloroethane; carbonochloridic acid 1-chloro-ethyl ester; tetrabutylammomium bromide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;